abstract：:Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are chronic inflammatory disorders that can affect the whole gastrointestinal tract or the colonic mucosal layer. Current therapies aiming to suppress the exaggerated immune response in IBD largely rely on compounds with non-satis...

journal_title：Frontiers in physiology

authors： Schreiber D,Marx L,Felix S,Clasohm J,Weyland M,Schäfer M,Klotz M,Lilischkis R,Erkel G,Schäfer KH

更新日期：2017-08-07 00:00:00

abstract：:Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...

journal_title：Frontiers in physiology

authors： Treff G,Winkert K,Sareban M,Steinacker JM,Becker M,Sperlich B

更新日期：2017-08-02 00:00:00

abstract：:Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small leuci...

journal_title：Frontiers in physiology

authors： Zvackova I,Matalova E,Lesot H

更新日期：2017-08-02 00:00:00

abstract：:The large amount of energy expended during flapping flight is associated with heat generated through the increased work of the flight muscles. This increased muscle work rate can manifest itself in core body temperature (Tb) increase of 1-2°C in birds during flight. Therefore, episodic body cooling may be mandatory in...

journal_title：Frontiers in physiology

authors： Guillemette M,Polymeropoulos ET,Portugal SJ,Pelletier D

更新日期：2017-07-25 00:00:00

abstract：:The recognition of invading pathogens and endogenous molecules from damaged tissues by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However, excessive TLR activation disrupts the immune homeostasis by sustained pro-inflammatory cytokines and chemokines production and consequently contributes...

journal_title：Frontiers in physiology

authors： Gao W,Xiong Y,Li Q,Yang H

更新日期：2017-07-19 00:00:00

abstract：:For early prevention of cardiovascular disease, early detection and risk factor insights are necessary. The autonomic balance reflects cardiovascular risk and can be measured by heart rate variability (HRV). Therefore, our purpose is to examine associations between HRV and the energy-related biomarkers leptin and adip...

journal_title：Frontiers in physiology

authors： Van De Wielle R,Michels N

更新日期：2017-07-12 00:00:00

abstract：:Dendrolimus punctatus Walker is a serious pest affecting conifers in southern China. As extensive pesticide spraying is currently required to control D. punctatus, new control strategies are urgently needed. Chemosensory genes represent potential molecular targets for development of alternative pest control strategies...

journal_title：Frontiers in physiology

authors： Zhang SF,Liu HH,Kong XB,Wang HB,Liu F,Zhang Z

更新日期：2017-07-07 00:00:00

abstract：:The ultrarapid delayed rectifier K+ current (IKur), mediated by Kv1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation (AF). Here, we combine targeted genetic engineering with cardiac...

journal_title：Frontiers in physiology

authors： Marczenke M,Piccini I,Mengarelli I,Fell J,Röpke A,Seebohm G,Verkerk AO,Greber B

更新日期：2017-07-06 00:00:00

abstract：:The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian...

journal_title：Frontiers in physiology

authors： Morton JS,Care AS,Kirschenman R,Cooke CL,Davidge ST

更新日期：2017-06-30 00:00:00

abstract：:Background: Previous studies have observed significant heterogeneity in the magnitude of change in measures of metabolic response to exercise training. There are a lack of studies examining the prevalence of non-responders (NRs) in children while considering other potential environmental factors involved such as biolo...

journal_title：Frontiers in physiology

authors： Alvarez C,Ramírez-Campillo R,Ramírez-Vélez R,Izquierdo M

更新日期：2017-06-29 00:00:00

abstract：:Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to be the main cause of aging and age-related diseases including cancer, diabetes and Parkinson's disease. Accordingly, mitochondria from old individuals have higher levels of ROS. However, ROS also participate in cellular signaling, are i...

journal_title：Frontiers in physiology

authors： Scialò F,Fernández-Ayala DJ,Sanz A

更新日期：2017-06-27 00:00:00

abstract：:Sarcopenia is defined as the progressive loss of muscle mass with age, and poses a serious threat to the physiological and psychological health of the elderly population with consequential economic and social burdens. Chronic low-grade inflammation plays a central role in the development of sarcopenia such that it alt...

journal_title：Frontiers in physiology

authors： Xia Z,Cholewa J,Zhao Y,Shang HY,Yang YQ,Araújo Pessôa K,Su QS,Lima-Soares F,Zanchi NE

更新日期：2017-06-22 00:00:00

abstract：:Cephalopods are unrivaled in the natural world in their ability to alter their visual appearance. These mollusks have evolved a complex system of dermal units under neural, hormonal, and muscular control to produce an astonishing variety of body patterns. With parallels to the pixels on a television screen, cephalopod...

journal_title：Frontiers in physiology

authors： How MJ,Norman MD,Finn J,Chung WS,Marshall NJ

更新日期：2017-06-19 00:00:00

abstract：:RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...

journal_title：Frontiers in physiology

authors： Kolliopoulou A,Taning CNT,Smagghe G,Swevers L

更新日期：2017-06-14 00:00:00

abstract：:Mature spermatozoa have highly condensed DNA that is essentially silent both transcriptionally and translationally. Therefore, post translational modifications are very important for regulating sperm motility, morphology, and for male fertility in general. Protein sumoylation was recently demonstrated in human and rod...

journal_title：Frontiers in physiology

authors： Brohi RD,Wang L,Hassine NB,Cao J,Talpur HS,Wu D,Huang CJ,Rehman ZU,Bhattarai D,Huo LJ

更新日期：2017-06-13 00:00:00

abstract：:The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the response of myofibrillar-MPS to ingestion of branched-chain amino aci...

journal_title：Frontiers in physiology

authors： Jackman SR,Witard OC,Philp A,Wallis GA,Baar K,Tipton KD

更新日期：2017-06-07 00:00:00

abstract：:We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

journal_title：Frontiers in physiology

authors： Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

更新日期：2017-05-31 00:00:00

abstract：:Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied. Bicuspid pulmonary valve disease is rare and a small numbers of case reports...

journal_title：Frontiers in physiology

authors： Bissell MM,Loudon M,Neubauer S,Myerson SG

更新日期：2017-05-31 00:00:00

abstract：:In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cell can express more than one connexin isoform, the formation of hetero...

journal_title：Frontiers in physiology

authors： Zhong G,Akoum N,Appadurai DA,Hayrapetyan V,Ahmed O,Martinez AD,Beyer EC,Moreno AP

更新日期：2017-05-29 00:00:00

abstract：:Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidat...

journal_title：Frontiers in physiology

authors： Li YY,Wu JJ,Yang XX,Geng HY,Gong G,Kim HJ

更新日期：2017-05-26 00:00:00

abstract：:Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as ...

journal_title：Frontiers in physiology

authors： Funamoto K,Ito T,Funamoto K,Velayo CL,Kimura Y

更新日期：2017-05-24 00:00:00

abstract：:Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, h...

journal_title：Frontiers in physiology

authors： Satou R,Sato M,Kimura M,Ishizuka Y,Tazaki M,Sugihara N,Shibukawa Y

更新日期：2017-05-23 00:00:00

abstract：:Many cell division processes have been conserved throughout evolution and are being revealed by studies on model organisms such as bacteria, yeasts, and protozoa. Cellular membrane constriction is one of these processes, observed almost universally during cell division. It happens similarly in all organisms through a ...

journal_title：Frontiers in physiology

authors： Beltrán-Heredia E,Almendro-Vedia VG,Monroy F,Cao FJ

更新日期：2017-05-19 00:00:00

abstract：:Nowadays, the common octopus (Octopus vulgaris) culture is hampered by massive mortalities occurring during early life-cycle stages (paralarvae). Despite the causes of the high paralarvae mortality are not yet well-defined and understood, the nutritional stress caused by inadequate diets is pointed out as one of the m...

journal_title：Frontiers in physiology

authors： Varó I,Cardenete G,Hontoria F,Monroig Ó,Iglesias J,Otero JJ,Almansa E,Navarro JC

更新日期：2017-05-17 00:00:00

abstract：:Since the mid-1980s magnetic resonance imaging (MRI) has been investigated as a non- or minimally invasive tool to probe kidney allograft function. Despite this long-standing interest, MRI still plays a subordinate role in daily practice of transplantation nephrology. With the introduction of new functional MRI techni...

journal_title：Frontiers in physiology

authors： van Eijs MJM,van Zuilen AD,de Boer A,Froeling M,Nguyen TQ,Joles JA,Leiner T,Verhaar MC

更新日期：2017-05-16 00:00:00

abstract：:In the mammalian ear, transduction of sound stimuli is initiated by K+ entry through mechano-sensitive channels into inner hair cells. K+ entry is driven by a positive endocochlear potential that is maintained by the marginal cell layer of the stria vascularis. This process requires basolateral K+ import by NKCC1 Na+-...

journal_title：Frontiers in physiology

authors： Tan H,Bungert-Plümke S,Fahlke C,Stölting G

更新日期：2017-05-15 00:00:00

abstract：:Insecticidal effects of Bacillus thuringiensis Cry toxins in hemocoel of larvae have not been properly evaluated. In the present study, hemocoelic injection of four representative Cry toxins i.e., Cry1Aa, Cry1Ab, Cry1Ac, and DOR5 to an economically important lepidopteran insect pest Achaea janata, induced larval morta...

journal_title：Frontiers in physiology

authors： Ningshen TJ,Chauhan VK,Dhania NK,Dutta-Gupta A

更新日期：2017-05-10 00:00:00

abstract：:The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...

journal_title：Frontiers in physiology

authors： Villa CR,Morales DLS

更新日期：2017-05-09 00:00:00

abstract：:Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate l...

journal_title：Frontiers in physiology

authors： Gambara G,Salanova M,Ciciliot S,Furlan S,Gutsmann M,Schiffl G,Ungethuem U,Volpe P,Gunga HC,Blottner D

更新日期：2017-05-05 00:00:00

abstract：:We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix m...

journal_title：Frontiers in physiology

authors： Alkharobi H,Beattie J,Meade J,Devine D,El-Gendy R

更新日期：2017-04-28 00:00:00

abstract：:In the quest for a viable non-gravity dependent method to "lift weights" in space, our laboratory introduced iso-inertial resistance (YoYo™) exercise using spinning flywheel(s), more than 25 years ago. After being thoroughly tested in individuals subjected to various established spaceflight analogs, a multi-mode YoYo™...

journal_title：Frontiers in physiology

authors： Tesch PA,Fernandez-Gonzalo R,Lundberg TR

更新日期：2017-04-27 00:00:00

abstract：:Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid baroreceptors. The aim of this study was to investigate the association between carotid IMT and the autonomic modulation of heart rate variability (HRV). Methods: A total of 101 subjects we...

journal_title：Frontiers in physiology

authors： Pereira VL Jr,Dobre M,Dos Santos SG,Fuzatti JS,Oliveira CR,Campos LA,Brateanu A,Baltatu OC

更新日期：2017-04-26 00:00:00

abstract：:Background: In an aging population, regular physical activity (PA) and exercise have been recognized as important factors in maintaining physical function and thereby preventing loss of independence and disability. However, (older) adults spent the majority of their day sedentary and therefore insight into the consequ...

journal_title：Frontiers in physiology

authors： van der Velde JHPM,Savelberg HHCM,van der Berg JD,Sep SJS,van der Kallen CJH,Dagnelie PC,Schram MT,Henry RMA,Reijven PLM,van Geel TACM,Stehouwer CDA,Koster A,Schaper NC

更新日期：2017-04-25 00:00:00

abstract：:Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, ...

journal_title：Frontiers in physiology

authors： Gillard L,Mayeur C,Robert V,Pingenot I,Le Beyec J,Bado A,Lepage P,Thomas M,Joly F

更新日期：2017-04-19 00:00:00

abstract：:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological...

journal_title：Frontiers in physiology

authors： Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

更新日期：2017-04-18 00:00:00

abstract：:The brain-gut axis plays a critical role in the regulation of different diseases, many of which are characterized by sympathetic dysregulation. However, a direct link between sympathetic dysregulation and gut dysbiosis remains to be illustrated. Bone marrow (BM)-derived immune cells continuously interact with the gut ...

journal_title：Frontiers in physiology

authors： Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

更新日期：2017-04-12 00:00:00

abstract：:The underlying mechanisms in the development of diabetic nephropathy are currently unclear and likely consist of a series of dynamic events from the early to late stages of the disease. Diabetic nephropathy is currently without curative treatments and it is acknowledged that even the earliest clinical manifestation of...

journal_title：Frontiers in physiology

authors： Schiffer TA,Friederich-Persson M

更新日期：2017-04-11 00:00:00

abstract：:Apolipophorin III (ApoLp-III) is a well-known hemolymph protein having a functional role in lipid transport and immune responses of insects. Here we report the molecular and functional characterization of Anopheles stephensi Apolipophorin-III (AsApoLp-III) gene. This gene consists of 679 nucleotides arranged into two ...

journal_title：Frontiers in physiology

authors： Dhawan R,Gupta K,Kajla M,Kakani P,Choudhury TP,Kumar S,Kumar V,Gupta L

更新日期：2017-04-07 00:00:00

abstract：:To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

journal_title：Frontiers in physiology

authors： Li S,Cui L,Zhang Y,Wang Y,Mao P

更新日期：2017-04-06 00:00:00

abstract：:Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (<10 nm), could regulate live cell function nanoscopically. The genetically-encoded protein photosensitizers (engineered fluorescent proteins such as KillerRed, TagRFP, and flavin-binding proteins such a...

journal_title：Frontiers in physiology

authors： Jiang HN,Li Y,Cui ZJ

更新日期：2017-04-04 00:00:00